888-677-6308

Transformation Program

Fortify
Protective Recovery

Ignite
Healthy Slimming

Optimize
Metabolic Liberator

Read Detail on Each Ingredient Below:

Ignite
SUPPLEMENT FACTS
Serving Size: 2 Capsules
Servings Per Container: 30
Amount Per Serving %Daily Value
Vitamin D 1,000IU 250%
Fat Burner Blend 677mg +
Irvingia gabonesis extract, Cissus quadrangularis extract, Sinetrol citrus extract, Bitter Orange, Black Pepper (Piper nigrum) extract
GoActive Blend 380mg +
Green Tea (Camellia sinensis) Extract, Octodrine
+ Daily Value not established.
Other Ingredients: Vegetarian capsule



Ingredients in IGNITE:

Cissus Quadrangularis

Cissus Quadrangularis, (a key ingredient in IGNITE) is a perennial plant that is part of the grape family. It is believed to be native to either Sri Lanka or India but is also found within Arabia, Southeast Asia, and Africa. It has also been imported to the southern United States and Brazil. Nicknamed “bone-setter”, it has been used for thousands of years for its medicinal properties. In Ayurvedic and Siddha medicines it is popularly used for pain relief, and to help heal injured tendons, bones, and ligaments.

Benefits of Cissus

Weight Loss Benefits - Several studies have confirmed the remarkable weight loss potential of Cissus Quadrangularis supplements:

  • Study 1) Those who took Cissus Quadrangularis lost 187 percent more weight in comparison to the placebo group. Researchers believe that this supplement can help burn fat, reduce appetite, and increase lean muscle mass. Since lean muscle mass supports a higher metabolism, you can burn more calories, even at rest.
  • Study 2) Another study compared the different effects of taking Cissus Quadranularis, a placebo, and using Cissus Quadrangularis in combination with a diet plan. After eight weeks, it was found that both groups taking Cissus Quadrangularis lost a significant amount of weight in addition to reducing their blood pressure, cholesterol, and triglycerides, while better balancing their blood sugar.

While these particular studies have some impressive findings, its also important to know how Cissus promotes weight loss.

  1. It may help balance blood sugar levels.1

    High blood sugar levels result in the body releasing insulin. Several studies have confirmed that the presence of insulin encourages the body to start storing fat. The higher the insulin levels – the more significant the weight gain can become. In a study where type 2 diabetic rats were administered Cissus Quadrangularis for 60 days, the treated rats showed a significant improvement in blood glucose levels1, liver toxicity markers, inflammatory and lipid peroxidation markers, as well as an increase in antioxidant activity. Since Cissus Quadrangularis helps control one’s blood sugar, it can also reduce one’s risk of becoming pre-diabetic and then developing type II diabetes, which is highly correlated with obesity.

  2. Cissus Quadrangularis can help improve gut health & trigger weight loss.2,4

    The latest research confirms that overweight and obese people tend to have bacterial imbalances in the digestive tract – which can ultimately have a negative effect on metabolism. Recent studies have confirmed Cissus’s long purported gut healing benefits – showing its ability to help heal the lining of the digestive tract, reduce inflammation, enhance antioxidant defenses, and control bacterial imbalances2. In a study involving rats with induce ulcers, Cissus Quandrangularis decreased gastric secretions and increased gastric mucin content and glycoprotein levels (R).In another study, rats with aspirin-induced ulcers were given cissus quadrangularis extract. Treated rats showed a reduction in the ulcer size and a restored protective mucus layer3. Further showing cissus’s shows antiulcer and gastroprotective benefits, another study showed that in rats that were given cissus quadrangularis, aspirin did not significantly affect the gastric mucosa in the ulcers of rats, whereas non treated rates showed depletion of gastric wall mucus, glycoproteins and gastric mucosal NPSH concentration3.

  3. Cissus Quadrangularis has powerful antioxidant and anti-inflammatory properties.

    We all know that antioxidants and anti-inflammatories are a good thing health-wise, but you may not know how this pertains to weight loss. Inflammation sends a signal to the brain telling it that there is an injury or malfunction somewhere. For our ancestors, who relied on their hunting and gathering skills to survive, an injury could be catastrophic to their ability to gather food. To help ensure survival during a period where food may be scarce, the body evolved to slow the metabolism down and start storing any excess energy it can. The body does not differentiate between inflammation caused by a crippling injury versus inflammation caused by a weak gut lining, stress, or a poor diet – they can all trigger the body into going into survival mode. Packed with vitamin C, Cissus is a natural antioxidant. Its ability to fight inflammation, which can reduce pain and swelling is probably a large part of its popularity for use as a pain killer in Ayurvedic and Siddha medicines. It has also been shown to help reduce LPS-induced free radical damage6, by helping reduce both inflammatory nitric oxide (iNOS) and the core inflammatory gene signal NF-kappaB. In a study determining Cissus’s protective qualities, liver damage was induced in rats – creating elevated levels of aspartate transaminase, alanine transaminase, alkaline phosphatase, and bilirubin - all toxic to the blood in high levels. Rats treated with methanol extract of Cissus Quadangularis showed a significant lowering of these levels, decreased lipid peroxidation and increased activity. Another recent study showed cissus quadrangularis to be highly protective of the liver3, offsetting the toxic effects of a TB drug by drastically reducing free radical damage. This is relevant to weight management, as the liver is often subject to inflammatory and free radical-producing insults coming from both the digestive tract and white adipose tissue. Thus, cissus quadrangularis helps offset metabolic stress associated with gut imbalance by a variety of mechanisms.
References/Studies:
Significantly reduces blood glucose increases, protects the liver, and Reduces inflammation and oxidative stress in diabetic rats (https://www.ncbi.nlm.nih.gov/pubmed/26321745)
1. Cissus Quadrangularis Helps Insulin Resistance and Metabolic Distress  Food Chem Toxicol.  Chidambaram J, Venkatraman AC.
2. Cissus Quadrangularis Supports Healthy Weight Loss  Lipids Health Dis.  Oben J, Kuate D, Agbor G, Momo C, Talla X.
3. Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease in rats fed high fat plus fructose diet. https://www.ncbi.nlm.nih.gov/pubmed/20450951
4. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570348/?tool=pubmed


Additional Benefits:

In addition to its fat-burning benefits, Cissus has been shown to be extremely beneficial to bone and joint health. Today, it’s currently used by athletes for exercise-related joint pain. When studying rats, it appeared to be an effective painkiller. Many health experts in the field have compared cissus quadrangularis to the same pain-relieving effects as aspirin.

Although few human studies have been conducted, one study focused on athletes and yielding positive effects. Those who took Cissus Quadrangularis experienced a reduction in joint pain by a third. This could be promising for athletes, as most joint health supplements do not report much athlete-based evidence, as most research is conducted on people with osteoarthritis.

Cissus Quadrangularis is best known for its potential ability to heal broken bones faster than normal – earning it its nickname, the Bone Setter. When studying dogs, it was proven that Cissus Quadrangularis offered healing effects. One group of dogs were given Cissus Quadrangularis while the other were given a placebo. After 21 days, those who were given a placebo had not healed, yet those who ingested Cissus Quadrangularis had healed completely.

A similar study was conducted in rats, as those who were given Cissus Quadrangularis healed 50 percent faster. While studying these effects, researchers believe that Cissus Quadrangularis may help increase the uptake of calcium. This makes sense, as calcium is one of the key nutrients that’s required for optimal bone strength. There’s also evidence suggesting that Cissus Quadrangularis taken every day could reduce the risk of fracturing a bone by up to 40 percent.

One study on cissus quadrangularis and bones shows that cissus quadrangularis works at the level of gene transcription to turn on osteoblasts and to specifically boost their production of osteocalcin1. This is a powerful finding, as it means that the nutrient is a bone-building gene regulator, elevating it to a new status of usefulness. Additionally, osteocalcin2 acts as a hormone elsewhere in your body by boosting adiponectin,3 production in your white adipose tissue, in turn helping protect against insulin resistance and cardiovascular inflammation4.

References/Studies:
  • ^ Cissus Quadrangularis Suports Osteoblast Function  Phytomedicine  Kumar M, Rawat P, Dixit P, Mishra D, Gautam AK, Pandey R, Singh D, Chattopadhyay N, Maurya R.
  • 1 ^ Cissus Quadrangularis Helps Bones Despite Loss of Ovaries  Ups J Med Sci  Potu BK, Rao MS, Nampurath GK, Chamallamudi MR, Prasad K, Nayak SR, Dharmavarapu PK, Kedage V, Bhat KM.
  • 2 ^ Cissus Quadrangularis and Animal Studies of Fracture Healing Rate
  • 3 ^ Cissus Quadrangularis:  A Pilot Study in Human Fracture Recovery  The Antiseptic  Thawani V; Kimmatkar N; Hingorani L; Khiyani R.
  • ^ Cissus Quadrangularis Boosts Bone Density in Perimenopausal Women    Deshmukh Vikrant, Khot R S, Thawani Vijay, Abhichandani L G, Goswami
  • Evidence-based assessment of antiosteoporotic activity of petroleum-ether extract of Cissus quadrangularis Linn. on ovariectomy-induced osteoporosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852762/?tool=pubmed
  • Anti-osteoporotic constituents from Indian medicinal plants. https://www.ncbi.nlm.nih.gov/pubmed/20554183
  • Osteogenic potential of cissus qudrangularis assessed with osteopontin expression https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800385/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763075/?tool=pubmed
  • Thawani V; Kimmatkar N; Hingorani L; Khiyani R. Effect of herbal combination containing Cissus quadrangularis in fracture healing. The Antiseptic 2002 September 99(9): 345-7
  • Dept. of Pharmacology, Govt. Medical College, Nagpur .http://medind.nic.in/imvw/imvw965.html
Study Abstract: Abstracts for these six studies are not available to the public.
  • 1.Chopra SS, Patel MR, and Awadhiya RP. Studies of Cissus quadrangularis in experimental fracture repair : a histopathological study. Indian J Med Res 64: 1365-1368, 1976.
  • 2.Chopra SS, Patel MR, Gupta LP, and Datta IC. Studies on Cissus quadrangularis in experimental fracture repair: effect on chemical parameters in blood. Indian J Med Res 63: 824-828, 1975.
  • 3.Udupa KN, Arnikar HJ, and Singh LM. Experimental studies of the use of ‘cissus quadrangularis’ in healing of fractures. II. Indian J Med Sci 15: 551-557, 1961.
  • 4.Udupa KN and Prasad G. Biomechanical and Calcium-45 Studies on the Effect of Cissus Quadrangularis in Fracture Repair. Indian J Med Res 52: 480-487, 1964.
  • 5.Udupa KN and Prasad GC. Cissus quadrangularis in healing of fractures. A clinical study. J Indian Med Assoc 38: 590-593, 1962.
  • 6.Udupa KN and Prasad GC. Further Studies on the Effect of Cissus Quadrangularis in Accelerating Fracture Healing. Indian J Med Res 52: 26-35, 1964.

What are the Potential Side Effects?

Since cissus quadrangularis is an all-natural supplement, it’s considered to be highly safe and side effects are rare. Within clinical studies, most participants did not experience any adverse effects at all. For those who did report side effects, they were mild in nature and included flatulence, headaches, and nausea.

Do not take if you are pregnant or breastfeeding, as there’s not enough information and research to confirm whether this is safe or not. Like most supplements, it may interfere with certain medications. Please discuss proper dosing with your doctor before taking cissus quadrangularis.

If you’re diabetic, speak with your doctor before taking cissus quadrangularis. Since it naturally lowers blood sugar, taking cissus quadrangularis along with your regular diabetic medications could cause your blood sugar to dip too low.

Irvingia Gabonensis (African Mango)

Irvingia Gabonensis (African Mango)

Irvingia Gabonesis, also know as African Mango, is a West Aftrican tree whose fruit is sweet, edible, and similar to a mango. Prized for its many uses, the bark, pulp, and seeds of the fruit are often used for medicinal purposes. Irvingia gabonensis is also known as Ogbono, dika, sweet bush mango, odika, iba-tree, chocolatier, African mango, dika nut, duiker nut, manguier sauvage, wild mango, and dika bread tree. 

Benefits of African Mango/Irvingia Gabonesis

Extract from the seeds of the fruit of Irvingia Gabonesis is proving to be useful in the fight against unwanted weight gain. It also helps promote healthy cholesterol, blood glucose, adiponectin, and leptin levels.

According to one study involving 40 obese subjects, those who took 150mg of this African mango seed extract twice a day showed "significant improvements" in their body weight, body fat, and waist size. The treated patients also had a significant decrease of total cholesterol, LDL-cholesterol, triglycerides, an increase of HDL-cholesterol, improved levels of blood glucose, C-reactive protein, adiponectin, and leptin levels – all without changing their diet or exercise routine. On the other hand, the placebo group did not manifest any changes in blood lipid components. Additional studies have shown similar results, with subjects losing weight (about 8-10 pounds) without making other lifestyle changes.

On average, participants in clinical studies saw a ten percent decrease in weight and waist measurements as well as a 50% increase in good cholesterol and 50% decrease in the inflammatory c-reactive protein.

One of the ways that Irvingia Gabonesis promotes weight loss is through its ability to boost leptin levels. Leptin is a hormone that helps suppress appetite as well as let our brain know when we have eaten enough. It also helps break down stored triglycerides in fat cells via lipolysis and delays stomach emptying – which helps prevent blood sugar spikes (which can lead to food cravings).

It also helps improve leptin sensitivity. Obese individuals have high blood levels of leptin, which is a sign that their cells have become resistant to the hormone that is supposed to prevent them from gaining so much weight. Irvingia has demonstrated beneficial effects on leptin blood levels, followed by both fat loss and acreduced waistline.2,3

Irvingia also benefits key aspects of healthy metabolism:

  • Glycerol-3-phosphate dehydrogenase — when we eat sugar or starchy foods, this enzyme is involved in converting those calories to body fat. Irvingia has been shown to reduce the activity of glycerol-3-phosphate dehydrogenase,2,4 helping to reduce starch and sugar calorie impact on body fat. 10
  • Alpha-amylase — scientific research suggests that irvingia can inhibit the alpha-amylase enzyme.5 This can help support a slower rate of carbohydrate absorption and reduce the caloric impact of starchy and sugary foods. 11
  • Adiponectin — irvingia helps support healthy levels of adiponectin,3 a hormone that helps maintain insulin sensitivity on the membranes of energy-producing cells. Large fat cells produce less adiponectin, which can put the system at risk of developing insulin resistance. Insulin resistance leads to excess insulin in the bloodstream, resulting in additional weight gain. Healthy levels of adiponectin are necessary to maintain a healthy weight.
References:
 
6] Matos L., Nzikou J. M., Matouba E. and Pandzou-Yembe V. N. (2009), Studies of Irvingia Gabonensis Seed Kernels: Oil Technological Application”, Pakistan Journal of Nutrition 8(2), pp. 151-156.
7] Ngondi, J., J. Oben and S. Minka, (2005), The effect of Irvingia gabonensis seeds on body weight and blood lipids of obese subject in Cameroon. Lipids Health Diseases, 4: p. 12.
8] Nwigbo S. C., Ngini J. O. and Atuanya C. U. (2013), Physical and Mechanical Properties of Irvingia Gabonesis and Irvingia wombolu at varying Moisture Content and Temperature, International Journal of Multidisciplinary Sciences and Engineering, vol. 4, no. 6, pp. 10-13.
9] Ogunsina S. B., Bhatnager S. S., Indira T. N. and Radha C. (2012), The Proximate Composition of African Bush Mango Kernels (Irvingia Gabonensis) and Char
10: Lipids Health  Dis. 2008 Nov 13;7:44.
11) Lipids Health  Dis. 2008 Mar 31;7:12.

 

 

Octodrine (aka.. DMHA or 2-Aminoisoheptane)

Octodrine (Also known as DMHA, 2-Aminoisoheptane)

Octodrine, also known as DMHA, is an extract derived from the fruit of the Kigelia Africana plant which has been a part of the South, central and West African diet since prehistoric times.

Used in traditional African medicine, the Kigelia Africana plant was prized for its anti-inflammatory 6a, pain relieving 5a - as well as respiratory benefits, which led to the commercial use of Octodrine in the 1950’s as a decongestant. 8a,10b

Energy Boosting Benefits

Octodrine is rapidly gaining popularity for its energy and mood boosting capabilities. This has made it particularly popular as a preworkout supplement since it has several qualities that ensure you get the most out of your workout: boosted energy levels (making it easier to push yourself and move more, which means more calories burned!), increased motivation (lots of energy doesn’t mean anything if you don’t have the desire to work out), and improved mood (when you feel good during and after your workout - it makes it more likely you will come back and do it all over again). Some other benefits include greater pain tolerance 5,6,  decreased rate of perceived exertion 5,6, and improving bronchodilation 3b,4b,5b - which come in handy when lifting weights, powering through a spin or HIIT class, or even wrangling kids and a house full of chores.

One of the best parts about Octodrine is that these benefits kick in fast thanks to its molecular structure. The addition of a methyl group on the alpha carbon increases the amphiphilic nature of the compound — which makes it both water-soluble and lipid-soluble. Increased lipid solubility dramatically increases its ability to pass through the blood brain barrier where it is able to exert its focus-enhancing and euphoric effects.8,9

Weight Loss Benefits

Octodrine can also help boost weight loss due to its ability to decrease appetite as well as improve your mood by increasing the hormones responsible for making you "feel good"4b,5b (say goodbye to binge sessions caused by stress and feeling down!) .

Octodrine’s mood boosting benefits stem from its ability to increase dopamine and norepinephrine levels, which are responsible for enhanced euphoria and wakefulness.3b,4b,5b,6b. Similar in structure and metabolically related to the classical monoamine neurotransmitters, Octodrine can activate trace amine associated receptor 1, while temporarily preventing the reuptake of dopamine and norepinephrine into the presynaptic nerve - improving its “punch” and lasting ability.

In addition, users of DMHA have reported a higher pain threshold and reduced fatigue, thus allowing users to gain maximum benefits from their workouts. Octodrine also induces motivation to do something. As already stated, DMHA triggers the release of dopamine. Dopamine levels influence motivation levels and the subsequent volition. Motivation is the desire to accomplish something while volition is the commitment. A person may wish to achieve something, but if they encounter hurdles along the way, then they may give up. However, if a person has volition, then they will not dissuaded from the cause until they achieve what they set out to do. Thankfully, dopamine, whose release is triggered by the intake of DMHA, ensures you have both the motivation and the volition to achieve your goals.

The combination of effects experienced when using DMHA provide the ultimate support for workouts, hence its increased inclusion in a variety of performance based, pre-workout supplements and drinks.

Pain Relief and Antiinflammatory benefits

Octodrine’s pain relieving and anti-inflammatory benefits extend beyond the ability to improve the benefits of a workout. It can also be useful for reducing daily aches and pains that can prevent or discourage one from doing things around the house, yard, or at work. The better you feel, the more you are able to get done.

(5) In a study performed in 2007 at the University of Benin, researchers confirmed the antiinflammatory and pain relieving benefits of Octodrine/Kigelia Africana extract. On mice and guinea pigs treated with the extract, they found a reduction of redness on irritated paws as well as a higher pain tolerance. Higher doses of the extract showed greater improvement.

(6) Additional studies were performed by John A. Wilkinson to determine the benefits of extracts derived from the fruit of the Kigelia Africana. Researchers, testing the extract on human neutrophils, found that the extract effectively inhibited Cyclooxygenase, which is responsible for converting Arachodonic Acid to pain mediators known as Prostaglandins. Prostaglandins are also responsible for triggering an inflammatory response. Inhibiting the COX and the resulting Prostaglandin production ultimately results in pain relief and reduced inflammation.

Concentration, Focus, and Memory Enhancing Benefits

Preliminary studies show that Octodrine is more effective than its predecessors, DMAA and AMP Citrate, at the ability to improve mental performance 17b,18b,19b. It can keep you alert and focused, allowing you to accomplish more.

Octodrine’s ability to influence the release of dopamine and norepinephrine - which studies show play a role in long term memory and recall, may contribute to improved study or learning efforts.

It also improves episodic memory17b, which, through past experiences, helps one to distinguish between approaches that work from the ones that don’t work. The ability to apply the same logic to solve new challenges saves time and resources.

Effective Against Candida

You may have heard of Candida, but you may not be aware of what a threat it is and the many problems it can cause. Candida albicans is an opportunistic species of yeast, or single-celled fungus, that is the fourth most common hospital-acquired infection in the U.S. and is the most common cause of fatal fungal infections in humans - costing around $2–4 billion dollars a year to treat.

Many people carry a Candida infection or overgrowth without realizing it. Some common symptoms associated with Candida are:

  1. Feeling tired or worn down - possibly suffering from Chronic Fatigue Syndrome or Fibromyalgia
  2. Digestive Issues such as bloating, diarrhea, or constipation
  3. Autoimmune diseases such as Hashimoto’s thyroiditis, Rheumatoid Arthritis, Ulcerative Colitis, Lupus, Scleroderma, or Multiple Sclerosis
  4. Difficulty concentrating, poor memory, lack of focus, ADD or ADHD
  5. Skin issues such as eczema, psoriasis, hives and rashes
  6. Skin and nail fungal infections such as athlete’s foot, ringworm, and toenail fungus
  7. Severe seasonal allergies
  8. Strong sugar or carb cravings
  9. Irritability, mood swings, depression, or anxiety
  10. Vaginal infections, urinary tract infections, rectal itching, or vaginal itching

Candida also has the ability to suppress the immune system so frequent illness or inability to recover quickly from illness may also be a sign.

During efforts to find effective treatments for fighting Candida, it was discovered that Octodrine, in addition to having the ability to fight and kill Candida, also displayed wide-spectrum anti-microbial activity. Compared to other selected anti-Candida drugs, Octodrine was shown to be one of the most effective drugs in killing serum-grown Candida albicans without significantly affecting the survival of host macrophages and skin cells. The fact that no C. albicans mutants showed a decrease in sensitivity to Octodrine argues against the potential emergence of Octodrine-resistant Candida strains - a powerful argument that favors the usage of this drug as a new antifungal treatment against Candida.

Antimicrobial properties of Octodrine

In addition to Octodrine’s ability to kill Candida albicans [2639], it has also displayed some impressive antimicrobial properties - capable of killing Gram-positive as well as Gram-negative bacteria. In one study, Octodrine killed a Uropathagenic strain of E. Coli bacteria after 5 days of exposure, and within a week, it killed everything the scientists tested for. (31b)

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462072/ 
[1] Kigelia africana (Lam.) Benth. http://pza.sanbi.org/kigelia-africana
[2] Comprehensive scientific demystification of Kigelia africana: A review. Olatunji A. Gabriel and Atolani Olubunmi. African Journal of Pure and Applied Chemistry September, 2009, Vol. 3 (9), pp. 158-164, Available online at http://www.academicjournals.org/AJPAC
[3] Kigelia africana (Lam.) Benth. (Sausage tree): Phytochemistry and pharmacological review of a quintessential African traditional medicinal plant. Bello I, Shehu MW, Musa M, Zaini Asmawi M, Mahmud R. J Ethnopharmacol. 2016 Aug 2;189:253-76. doi: 10.1016/j.jep.2016.05.049. Review.
[4] Metabolomic Profiling of Kigelia africana Extracts with Anti-Cancer Activity by High Resolution Tandem Mass Spectroscopy. Pharmacognosy Communications; Oct–Dec 2014, Volume 4, Issue 4, p10-22. Retrieved from http://www98.griffith.edu.au/dspace/bitstream/handle/10072/64248/98347_1.pdf
[5] Analgesic and anti- inflammatory activities of the ethanolic stem bark extract of Kigelia africana
(Bignoniaceae) Omonkhelin. J. Owolabi and Eric. K. I. Omogbai. African Journal of Biotechnology Vol. 6 (5), pp. 582-585, 5 March, 2007 Available online at http://www.academicjournals.org/AJB
[6] Anti-inflammatory and other effects of Kigelia africana extracts. by Dr John A. Wilkinson
Director, Herbal Sciences International Ltd, UK. Consultants to the Natural Products Industry. www.phytochemistry.freeserve.co.uk   www.herbalsciencesinternational.com  www.phytotradeafrica.com
[7]  “The pharmacology of 2-amino-6-methylheptane”; Fellows, E., The Journal of pharmacology and experimental therapeutics; August 1947, 90(4):351-8;; Retrieved from http://www.webcitation.org/6edUQGu7m
[8] The National Museum of American History, Kenneth E. Behring Center; “Eskay’s Oralator”; The Smithsonian Institute; 1984; Retrieved from http://americanhistory.si.edu/collections/search/object/nmah_737864
B)
Lin, C., Chan, T., & Deng, J. “Clinical features and management of herb-induced aconitum poisoning”; Annals of emergency Medicine, 43(5): 574-579; 2004; Retrieved from http://www.sciencedirect.com/science/article/pii/S0196064403011314
  • Rasmussen, N., & Keizers, P; “History Full Circle: Novel sympathomimetics in supplements” Drug testing and analysis; 2015; Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/dta.1852/abstract
  • Millan, M; “The role of monoamines in the actions of established and novel antidepressant agents: a critical review”; European Journal of Pharmacology; 500(1): 371-384; 2004. Retrieved from http://www.sciencedirect.com/science/article/pii/S0014299904007472
  • Fleckenstein, A., Volz, T., Riddle, E., Gibb, J., & Hanson, G; “New Insights into Mechanism of Action of Amphetamines”; Annual review of Pharmacology and Toxicology; 47: 681-698; 2007. Retrieved from http://www.annualreviews.org/doi/abs/10.1146/annurev.pharmtox.47.120505.105140
  • Wise, R., & Bozarth, M; “Brain Mechanism of Drug Reward and Euphoria”; Journal of Psychiatric Medicine, 3(4): 445-460; 1985. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/2893431
  • Millerm G; “The emerging role of Trace Amine Associated Receptor 1 in the Functional Regulation of Monoamine Transporters and Dopaminergic Activity”; Journal of Neurochemistry, 116(2): 164-176; 2011. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005101/
  • Sullivan, J., & Tipton, K; “The interactions of monoamine oxidase with some derivatives of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)”; Journal of Neural Transmission, 29: 269-277; 1990. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/2358804
  • Vauzour D, Vafeiadou K, Rodriguez-Mateos A, Rendeiro C, and Spencer JPE; “The neuroprotective potential of flavonoids:a multiplicity of effects”; Genes Nutr. 3(3-4): 115–126; 2008. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593006/
  • Svenningsson P, Nomikos GG, Fredholm BB; “The stimulatory action and the development of tolerance to caffeine is associated with alterations in gene expression in specific brain regions”; J Neurosci; 19(10):4011–4022; 1999. Retrieved from http://www.jneurosci.org/content/19/10/4011.full.pdf
  • Putu Biotec; “Octodrine-CAS No.-543-82-8”; Retrieved from http://www.putubio.com/octodrine-cas-no-543-82-8/
  • The National Museum of American History, Kenneth E. Behring Center; “Eskay’s Oralator”; The Smithsonian Institute; 1984; Retrieved from http://americanhistory.si.edu/collections/search/object/nmah_737864
  • Hutcheon, D, McCullough, L; “The Respiratory Stimulant Action of Octylamines”; British Journal of Pharmacology; 7, 42; 1952; Retrieved from http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.1952.tb00688.x/pdf
  • Charlier, R; “Pharmacology of 2-amino-6-methyl-heptane”; Archives internationales de pharmacodynamie et de thérapie; 85(1-2):144-51; January 1951; Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/14820395
  • Fellows, E; “The pharmacology of 2-amino-6-methylheptane”; The Journal of pharmacology and experimental therapeutics; 90(4):351-8; August 1947; Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20265812
  •  
  • Fellows, E; “The pharmacology of 2-amino-6-methylheptane”; The Journal of pharmacology and experimental therapeutics; 90(4):351-8; August 1947; Retrieved from http://www.webcitation.org/6edUQGu7m
  • Jern, S; “Infusion of epinephrine augments pressor responses to mental stress”; Hypertension; 18(4):467-74; October 1991; Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/1655647
  • Fisher Scientific; 2-Amino-6-methylheptane Safety Data Sheet; February 10, 2015; Retrieved from https://www.fishersci.com/shop/msdsproxy?productName=AC116301000&productDescription=2-AMINO-6-METHYLHEPTANE%252C+100GR&catNo=AC11630-1000&vendorId=VN00032119&storeId=10652 (backed up at http://www.webcitation.org/6edZXwUUb)
  • Chowdhury, R et al; “Dopamine modulates episodic memory persistence in old age”; Journal of Neuroscience; 32(41): 14193-14204; 2012. Retrieved from http://www.jneurosci.org/content/32/41/14193.short
  • Wise, R; “Dopamine, learning and motivation”; Nature Reviews Neuroscience; 5: 483-494; 2004. Retrieved from http://www.nature.com/nrn/journal/v5/n6/abs/nrn1406.html
  • Richter-Levin, G., & Akirav, I; “Emotional tagging of memory formation – in the search for neural mechanisms”; Brain Research Reviews; 43(3): 247-256; 2003. Retrieved from http://www.sciencedirect.com/science/article/pii/S0165017303002248
  • Tully, K., & Bolshakov, V; “Emotional enhancement of memory: how norepinephrine enables synaptic plasticity”; Molecular Brain, 3(15); 2010. Retrieved from http://molecularbrain.biomedcentral.com/articles/10.1186/1756-6606-3-15
  • Horvitz, J; “Dopamine, Parkinson’s and Volition”; Journal of Behavioural and Brain sciences; 25(5): 586-586; 2002. Retrieved from http://journals.cambridge.org/action/displayAbstract?aid=172403
  • Whitehead, P., Schilling, B., Farney, T., & Bloomer, R; “Impact of a Dietary Supplement Containing 1,3-Dimethylamylamine on Blood Pressure and Bloodborne Markers of Health: a 10-Week Intervention Study”; Nutrition and metabolic insights, 5: 33-39; 2012. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698473/
  • Whitehead, P., Schilling, B., Farney, T., & Bloomer, R; “Hemodynamic and Hematologic Profile of Healthy Adults Ingesting Dietary Supplements Containing 1,3-Dimethylamylamine and Caffeine”; Nutrition and metabolic insights, 5: 1-12; 2012. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698476/
  • Food and Drug Administration; “Implementation of the Dietary Supplement Health and Education Act (DSHEA) of 1994”; Retrieved from http://www.fda.gov/NewsEvents/Testimony/ucm115082.htm
  • World Anti-Doping Agency; “Prohibited List”; January 2016. Retrieved from https://wada-main-prod.s3.amazonaws.com/resources/files/wada-2016-prohibited-list-en.pdf
  • Schilling, Brian K et al; “Physiological and Pharmacokinetic Effects of Oral 1,3-Dimethylamylamine Administration in Men.” BMC Pharmacology & Toxicology; 14: 52; 2013. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852303/
  • Miya, T, Edwards, L; “A pharmacological study of certain alkoxyalkylamines”; Journal of the American Pharmaceutical Association. American Pharmaceutical Association; 42(2):107-10; February 1953. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/13034643/
  • Kim, Kevin, Zilbermintz, Leeor, Martchenko, Mikhail; “Repurposing FDA approved drugs against the human fungal pathogen, Candida albicans”; Annals of Clinical Microbiology and Antimicrobials; 14:32; June 9, 2015. Retrieved from http://ann-clinmicrob.biomedcentral.com/articles/10.1186/s12941-015-0090-4
  • Niu, Hongxia, et al; “Identification of Anti-Persister Activity against Uropathogenic Escherichia coli from a Clinical Drug Library”; Antibiotics; 4(2), 179-187; 2015. Retrieved from http://www.mdpi.com/2079-6382/4/2/179/pdf
  • Kim, Kevin, Martchenko, Mikhail; “Method of treating microbial infections”; US Patent and Trademark Office; US Patent US20150196499 A1; July 16, 2015; Retrieved from https://www.google.com/patents/US20150196499
  • truthornothin; PHForum; September 16, 2013; Retrieved from http://www.prohormoneforum.com/index.php/topic/77372
  • Bromley, Philip J, Edelmann, Paul; “Compositions containing aminoalkanes and aminoalkane derivatives”; US Patent Filing; February 10, 2010; Retrieved from https://www.google.com/patents/US20100041622
  • Wikipedia; “Kefauver Harris Amendment”; Retrieved from https://en.wikipedia.org/wiki/Kefauver_Harris_Amendment
  • Ismet, Ara, et al; “Evaluation of Antimicrobial Properties of Two Different Extracts of Juglans regia Tree Bark and Search for Their Compounds Using Gas Chromatography-Mass Spectrum”; International Journal of Biology; Vol. 5, No. 2; 2013; Retrieved from http://www.ccsenet.org/journal/index.php/ijb/article/view/25651/15862
  • Arkhipov, A, et al; “Metabolomic Profiling of Kigelia africana Extracts with Anti-Cancer Activity by High Resolution Tandem Mass Spectroscopy”; Pharmacognosy Communications; Volume 4, Issue 4; Oct–Dec 2014; Retrieved from http://www98.griffith.edu.au/dspace/bitstream/handle/10072/64248/98347_1.pdf
  • Sinetrol Citrus Extract

    Sinetrol citrus extract is a patented, proprietary blend of several polyphenolic compounds extracted from various citrus fruits including orange, blood orange, and grapefruit. It combines these bioactive polyphenols, which include narigin, hesperedin and neohesperidin, with guarana extract – whose caffeine content can boost energy and focus. Sinetrol is designed to reduce body fat levels, enhance Lipolysis, reduce waist and hip circumference, and reduce oxidative stress and inflammation. Sinetrol helps to reduce body fat percentage by inhibiting the PDE-4 enzyme, which is responsible for the breakdown of cyclic adenosine monophosphate (cAMP). When a hormone like adrenaline interacts with fat cells, cAMP ensures the proper signal is sent to the enzymes- triggering the release of fatty acids from the cells into the bloodstream to be used for energy. Higher concentrations of cAMP mean more efficient fatty acid release, resulting in improved fat burning and an increase in energy levels.

    Black Pepper Extract

    Piperine in black pepper has been shown to reduce fat levels in the bloodstream as well as antioxidant benefits. It has a long history of use in Eastern medicine for treating gastrointestinal issues and inflammation, but it is its ability to interfere with the activity of genes that are responsible for fat formation that has scientists claiming it has weight-loss potential. Piperine has also been shown to significantly improve the absorption and bioavailability of the nutrients in food and supplements.

    Bitter Orange Extract (synephrine)

    Bitter Orange Extract is a patented complex that contains p-synephrine, n-methyltyramine, hordenine, octopamine, and tyramine and is designed to boost the metabolism, suppress hunger, and encourage fat breakdown. Advantra-Z works as a thermogenic, which increases the internal heat of the body, resulting in increased energy and metabolic rate. It has been shown to increase lipolysis – the breakdown of fats and other lipids, resulting in weight loss and improved energy levels. The fat-burning benefits are given a substantial boost when combined with green tea extract or caffeine.

    Green Tea Extract

    An effective fat-burner and focus-enhancer, green tea extract works due to the mix of caffeine and catechins ; effectively revving up your production of noradrenaline, a neurotransmitter that affects the levels of vigilance, attention, motivation, reward, learning, and memory.

    Vitamin D-3

    Adequate Vitamin D3 levels are essential for optimal health, however millions of individuals are severely deficient and thus deprived of its life-sustaining, bone-building, and immune modulating properties. Research shows that Vitamin D3 deficiency is linked to a variety of health conditions such as depression, back pain, cancer, insulin resistance, decreased immunity, osteopenia, and fibromyalgia. In addition to its long-established benefits for improving bone health, Vitamin D3 has been shown to improve cognitive function and symptoms of depression. Recent data has linked a correlation between Vitamin D3 deficiency and obesity – prompting researchers to suggest all overweight and obese people to have their levels tested.

    Juglans Regia Tree Bark Extract

    Juglans Regia Tree Bark Extract is obtained from the bark of the English Walnut Tree. There are two forms, the naturally derived version scientifically known as 2-amino-5-methylheptane and the cheaper, synthetic version known as 2-amino-6-methylheptane (Octodrine/DMHA). Although very similar in effect, it is believed that the natural version has a better absorption rate and a more potent effect than the synthetic counterpart.

    Juglans Regia Tree Bark Extract Benefits:

    Increased Energy

    One of the key attractions to Juglans Regia Tree Bark Extract is that it provides a smooth and effective boost of energy. It is often used as an alternative to caffeine in an effort to provide a smoother, more comfortable energy without the jitters or subsequent crash associated with high levels of caffeine.

    Increased Pain Threshold

    Another reason Juglans Regia Extract has become popular for use within the body building and fitness industry is that it not only provides extra energy, but it also can increase the pain threshold

    Increased Focus, Concentration, and Energy

    The attraction of Juglans Regia Extract has extended beyond the gym, however, as students are discovering its reputation as a “smart drug” - a supplement that can enhance or improve cognitive functions such as memory, focus, creativity, and motivation. They are using it to help them study longer, remember more, and be more productive. For this reason, it has also become popular for those wanting to get more done around at home or at the office.

    Improved Mood and Motivation

    Juglans Regia Extract has a similar molecular structure to other monoamine releasing agents, which can potentially increase feel good agents such as dopamine and noradrenaline. Higher levels of these monoamines can result in a better mood as well as increased motivation.

    Weight Loss

    The energy boost, increased focus and motivation and heightened pain threshold associated with Juglans Regia supplements can help one push their workouts - resulting in more burned calories at the gym. It is also a thermogenic fat burner that ramps up the metabolic rate and fat burning. It is also a powerful appetite suppressant so it can reduce snacking and other poor eating habits caused by cravings.

    Antioxidant and Anti-inflammatory Benefits

    The benefits of Juglans Regia Extract extend beyond its stimulant and fat burning capabilities.

    Widely used in Ancient Chinese Herbal Medicine, modern medicine has found it to have antioxidant, anti-inflammatory, and anti proliferative properties.
    (https://www.ncbi.nlm.nih.gov/pubmed/17207309)

    Candida Reducing Benefits

    One surprising and little known benefit to Juglans Regia Extract is that it is an effective and safe option to treat Candida overgrowth, a fungal pathogen that can disrupt gut health - affecting nutrient absorption, sugar cravings, inflammation levels, anxiety levels, attention span, as well as other health issues.

    Conclusion

    Juglans Regia has shown in studies to have numerous health benefits.  There are currently no known or published side affects or complications with the ingredient, but as always speak to your doctor before starting or stopping any supplement or medication.

     

    Studies and References:
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462072/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628521/
    https://www.ncbi.nlm.nih.gov/pubmed/17207309

     

    *This product has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
    As always, use with a sensible diet and exercise program. Individual results may vary.