|Amount Per Serving||%Daily Value|
|Fat Burner Blend||677mg||+|
|Irvingia gabonesis extract, Cissus quadrangularis extract, Sinetrol citrus extract, Bitter Orange, Black Pepper (Piper nigrum) extract|
|Green Tea (Camellia sinensis) Extract, Eria Jarensis extract|
|+ Daily Value not established.|
|Other Ingredients: Vegetarian capsule|
Cissus Quadrangularis, (a key ingredient in IGNITE) is a perennial plant that is part of the grape family. It is believed to be native to either Sri Lanka or India but is also found within Arabia, Southeast Asia, and Africa. It has also been imported to the southern United States and Brazil. Nicknamed “bone-setter”, it has been used for thousands of years for its medicinal properties. In Ayurvedic and Siddha medicines it is popularly used for pain relief, and to help heal injured tendons, bones, and ligaments.
Benefits of Cissus
Weight Loss Benefits - Several studies have confirmed the remarkable weight loss potential of Cissus Quadrangularis supplements:
While these particular studies have some impressive findings, its also important to know how Cissus promotes weight loss.
In addition to its fat-burning benefits, Cissus has been shown to be extremely beneficial to bone and joint health. Today, it’s currently used by athletes for exercise-related joint pain. When studying rats, it appeared to be an effective painkiller. Many health experts in the field have compared cissus quadrangularis to the same pain-relieving effects as aspirin.
Although few human studies have been conducted, one study focused on athletes and yielding positive effects. Those who took Cissus Quadrangularis experienced a reduction in joint pain by a third. This could be promising for athletes, as most joint health supplements do not report much athlete-based evidence, as most research is conducted on people with osteoarthritis.
Cissus Quadrangularis is best known for its potential ability to heal broken bones faster than normal – earning it its nickname, the Bone Setter. When studying dogs, it was proven that Cissus Quadrangularis offered healing effects. One group of dogs were given Cissus Quadrangularis while the other were given a placebo. After 21 days, those who were given a placebo had not healed, yet those who ingested Cissus Quadrangularis had healed completely.
A similar study was conducted in rats, as those who were given Cissus Quadrangularis healed 50 percent faster. While studying these effects, researchers believe that Cissus Quadrangularis may help increase the uptake of calcium. This makes sense, as calcium is one of the key nutrients that’s required for optimal bone strength. There’s also evidence suggesting that Cissus Quadrangularis taken every day could reduce the risk of fracturing a bone by up to 40 percent.
One study on cissus quadrangularis and bones shows that cissus quadrangularis works at the level of gene transcription to turn on osteoblasts and to specifically boost their production of osteocalcin1. This is a powerful finding, as it means that the nutrient is a bone-building gene regulator, elevating it to a new status of usefulness. Additionally, osteocalcin2 acts as a hormone elsewhere in your body by boosting adiponectin,3 production in your white adipose tissue, in turn helping protect against insulin resistance and cardiovascular inflammation4.
What are the Potential Side Effects?
Since cissus quadrangularis is an all-natural supplement, it’s considered to be highly safe and side effects are rare. Within clinical studies, most participants did not experience any adverse effects at all. For those who did report side effects, they were mild in nature and included flatulence, headaches, and nausea.
Do not take if you are pregnant or breastfeeding, as there’s not enough information and research to confirm whether this is safe or not. Like most supplements, it may interfere with certain medications. Please discuss proper dosing with your doctor before taking cissus quadrangularis.
If you’re diabetic, speak with your doctor before taking cissus quadrangularis. Since it naturally lowers blood sugar, taking cissus quadrangularis along with your regular diabetic medications could cause your blood sugar to dip too low.
Irvingia Gabonesis, also know as African Mango, is a West Aftrican tree whose fruit is sweet, edible, and similar to a mango. Prized for its many uses, the bark, pulp, and seeds of the fruit are often used for medicinal purposes. Irvingia gabonensis is also known as Ogbono, dika, sweet bush mango, odika, iba-tree, chocolatier, African mango, dika nut, duiker nut, manguier sauvage, wild mango, and dika bread tree.
Benefits of African Mango/Irvingia Gabonesis
Extract from the seeds of the fruit of Irvingia Gabonesis is proving to be useful in the fight against unwanted weight gain. It also helps promote healthy cholesterol, adiponectin, and leptin levels.
According to one study involving 40 obese subjects, those who took 150mg of this African mango seed extract twice a day showed "significant improvements" in their body weight, body fat, and waist size. The treated patients also had a significant decrease of total cholesterol, LDL-cholesterol, triglycerides, an increase of HDL-cholesterol, improved levels of blood glucose, C-reactive protein, adiponectin, and leptin levels – all without changing their diet or exercise routine. On the other hand, the placebo group did not manifest any changes in blood lipid components. Additional studies have shown similar results, with subjects losing weight (about 8-10 pounds) without making other lifestyle changes.
On average, participants in clinical studies saw a ten percent decrease in weight and waist measurements as well as a 50% increase in good cholesterol and 50% decrease in the inflammatory c-reactive protein.
One of the ways that Irvingia Gabonesis promotes weight loss is through its ability to boost leptin levels. Leptin is a hormone that helps suppress appetite as well as let our brain know when we have eaten enough. It also helps break down stored triglycerides in fat cells via lipolysis and delays stomach emptying – which helps prevent food cravings.
It also helps improve leptin sensitivity. Obese individuals have high blood levels of leptin, which is a sign that their cells have become resistant to the hormone that is supposed to prevent them from gaining so much weight. Irvingia has demonstrated beneficial effects on leptin blood levels, followed by both fat loss and acreduced waistline.2,3
Irvingia also benefits key aspects of healthy metabolism:
Sinetrol citrus extract is a patented, proprietary blend of several polyphenolic compounds extracted from various citrus fruits including orange, blood orange, and grapefruit. It combines these bioactive polyphenols, which include narigin, hesperedin and neohesperidin, with guarana extract – whose caffeine content can boost energy and focus. Sinetrol is designed to reduce body fat levels, enhance Lipolysis, reduce waist and hip circumference, and reduce oxidative stress and inflammation. Sinetrol helps to reduce body fat percentage by inhibiting the PDE-4 enzyme, which is responsible for the breakdown of cyclic adenosine monophosphate (cAMP). When a hormone like adrenaline interacts with fat cells, cAMP ensures the proper signal is sent to the enzymes- triggering the release of fatty acids from the cells into the bloodstream to be used for energy. Higher concentrations of cAMP mean more efficient fatty acid release, resulting in improved fat burning and an increase in energy levels.
Adequate Vitamin D3 levels are essential for optimal health, however millions of individuals are severely deficient and thus deprived of its life-sustaining, bone-building, and immune modulating properties. Research shows that Vitamin D3 deficiency is linked to a variety of health conditions such as depression, back pain, cancer, insulin resistance, decreased immunity, osteopenia, and fibromyalgia. In addition to its long-established benefits for improving bone health, Vitamin D3 has been shown to improve cognitive function and symptoms of depression. Recent data has linked a correlation between Vitamin D3 deficiency and obesity – prompting researchers to suggest all overweight and obese people to have their levels tested.